In vivo Efficacy of STX213, A Second-Generation Steroid Sulfatase Inhibitor, for Hormone-Dependent Breast Cancer Therapy
Purpose: Steroid sulfatase (STS) inhibitors that can decrease or prevent the biosynthesis of
estrogenic steroids via the sulfatase route may play an important role in the treatment of
breast cancer. We compare the in vivo efficacy of two potent STS inhibitors, STX64 and
STX213, in a xenograft breast cancer model. Experimental Design: MCF-7 cells stably
expressing STS cDNA (MCF-7STS) were generated. Ovariectomized MF-1 female nude
mice receiving sc injections of estradiol sulfate (E2S) and bearing both MCF-7STS and wild …
estrogenic steroids via the sulfatase route may play an important role in the treatment of
breast cancer. We compare the in vivo efficacy of two potent STS inhibitors, STX64 and
STX213, in a xenograft breast cancer model. Experimental Design: MCF-7 cells stably
expressing STS cDNA (MCF-7STS) were generated. Ovariectomized MF-1 female nude
mice receiving sc injections of estradiol sulfate (E2S) and bearing both MCF-7STS and wild …
[PDF][PDF] In vivo Efficacy of STX213, A Second-Generation Steroid Sulfatase Inhibitor, for Hormone-Dependent Breast Cancer Therapy
LLW Woo, BVL Potter, MJ Reed, A Purohit - researchgate.net
Purpose: Steroid sulfatase (STS) inhibitors that can decrease or prevent the biosynthesis of
estrogenic steroids via the sulfatase route may play an important role in the treatment of
breast cancer. We compare the in vivo efficacy of two potent STS inhibitors, STX64 and
STX213, in a xenograft breast cancer model. Experimental Design: MCF-7 cells stably
expressing STS cDNA (MCF-7STS) were generated. Ovariectomized MF-1female nude mice
receiving sc injections of estradiol sulfate (E2S) and bearing both MCF-7STS and wild-type …
estrogenic steroids via the sulfatase route may play an important role in the treatment of
breast cancer. We compare the in vivo efficacy of two potent STS inhibitors, STX64 and
STX213, in a xenograft breast cancer model. Experimental Design: MCF-7 cells stably
expressing STS cDNA (MCF-7STS) were generated. Ovariectomized MF-1female nude mice
receiving sc injections of estradiol sulfate (E2S) and bearing both MCF-7STS and wild-type …
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